1.      Synthesis and structural characterization of organic-inorganic nanoparticles.

3.      In vivo bio-distribution of particles with different surface charges by optical image system and intravital optical image system with the liver chamber.

4.      Nanoparticles for cancer diagnosis and therapy.

5.      Mesoporous silica nanoparticles for biomedical applications especially in photodynamic therapy.

6.      Muti-functional mesostructured materials for controlled Release of cancer drug, contrast agents and tumor targeting. 

 

 

1. Cheng, S. H.; Liao, W. N.; Chen, L.M. and Lee, C.H. “pH-controllable release using functionalized mesoporous silica nanoparticles as an oral drug delivery system” J. Mater. Chem. 2011; doi: C0JM04490C. 【SCI, Rank 18/214, IF: 4.795】

2. Huang, I. P.; Sun, S. P.; Cheng, S. H.; Lee, C.H.; Wu, C. Y.; Yang, C. S.; Lo, L. W., and Lai, Y. K. “Enhanced Chemotherapy of Cancer Using pH-Sensitive Mesoporous Silica Nanoparticles to Antagonize P-Glycoprotein-Mediated Drug Resistance, ” Mol Cancer Ther 2011; doi:10.1158/1535-7163. 【SCI, Rank 28/166, IF: 4.953】

3.Cheng, S.H. and Lo, L.W. “Inorganic Nanoparticles for Enhanced Photodynamic Cancer Therapy,” Current Drug Discovery Technologies 2011 【Invited Review for special issue】.

4.Jeng, C. C.; Cheng, S. H.; Ho, J.-A.A.; Huang, S. H.-Y.; Chang, J. C.; Tsai, P. J.; Yang, C. S.and Lo, L.W. "Dynamic Probing of Nanoparticle Stability In Vivo: A Liposomal Model Assessed Using In Situ Microdialysis and Optical Imaging," J. NanoMat. 2010 JNM/932719 【Invited Paper, SCI, Rank 45/59, IF:1.023】.

5.Lee, C. H.; Cheng, S. H.; Huang, I. P.; Souris, J. S.; Yang, C. S. Mou, C. Y. and Lo, L. W. “Intracellular pH-Responsive Mesoporous Silica Nanoparticles for Controlled Release of Anticancer Chemotherapeutics” Angew. Chem.-Int. Edit. 2010 Accepted. 【Co-first author, SCI, Rank 5/140, IF:11.829】

6. Cheng, S. H.; Lee, C. H.;Chen, M. C.; Souris, J. S.; Tseng, F. G., Yang, C. S.;Mou, C. Y.; Chen, C.T.; Lo, L.W. “Tri-Functionalization of Mesoporous Silica Nanoparticles for Comprehensive Cancer Theranostics- the Trio of Imaging, Targeting and Therapy” J. Mater. Chem. 2010, 20, 6149. 【Interviewed and Selected by Chem. Commun.- Highlights in Chemical Biology; SCI, Rank 18/214, IF: 4.795】

7. Souris, J. S.; Lee, C. H.; Cheng, S. H.; Chen, C. T.; Yang, C. S.; Ho, J. A.; Mou, C. Y.; Lo, L. W. “Surface Charge-Mediated Rapid Hepatobiliary Excretion of Mesoporous Silica Nanoparticles” Biomaterials 2010, 31, 5564.【SCI, Rank 1/25, IF:7.365】

8.ChenChen, W.W.; Souris “Enhanced photoacoustic stability of gold nanorods by silica matrix confinement【SCI, Rank 9/71, IF:2.501】” J. Biomed. Opt. 2010, 15, 016010. , J. S.; Cheng, S. H.; Chen, C. T.; Yang, C. S.; Li, P. C.; Lo, L. W., L. C.;

9. Chen, L.C., Chen, W.W., Souris, J.S., Cheng, S.H., Yang, C.S., Chen, C.T., Li, P.C., and Lo, L.W. Enhanced photoacoustic stability of gold nanorods by silica matrix confinement. Virtual Journal of Biological Physics Research, Volume 19, Issue 4, Section: Instrumentation Development. 【Selected by the American Physical Society and the American Institute of Physics】

10.Lee, C. HHydroxo-Bridged Dinuclear Cupric Complexes Encapsulated in Various Mesoporous Silicas to Mimic the Catalytic Activity of Catechol Oxidases: Reactivity and Selectivity Study” J. Phys. Chem. C 2009, 113, 16058. .; Lin, H. C【SCI, Rank 22/214, IF:4.224】.; Cheng, S.H.; Lin, T. S.; Mou, C. Y. “

11.Cheng, S. H.; Lee, C. H.; Yang, C. S.; Tseng, F. G.; Mou, C. Y.; Lo, L. W. ” Mesoporous Silica Nanoparticles Functionalized with Oxygen-Sensing Probe for Cell Photo-Therapy as Potential Cancer Theranostics” J. Mater. Chem. 2009,19, 1252. 【Journal Cover; SCI, Rank 18/214, IF: 4.795】

12. Lee, C. H.; Cheng, S. H.; Wang, Y. J.;Chen, Y. C.;Chen, N. T.;Souris, J.;Chen, C. T.;Mou, C. Y.; Yang, C. S.;Lo, L. W. ”Near-infrared Mesoporous Silica Nanoparticles for Optical Imaging: Characterization and In Vivo Biodistribution” Adv. Funct. Mater. 2009, 19, 215.【SCI, Rank 11/214, IF:6.990】

13.”Fluorescence relaxation dynamics of donor-acceptor molecules in solvents of various polarities.”

14. Hong-Wei Liu, H. W.; Laskar I. R.; Huang, C.P.; Cheng, J. A. ; Cheng, S. H. ; Luo, L. Y.; Wang, H. R. ; Chen, T. M. “Enhanced phosphorescence and electroluminescence in triplet emitters by doping gold into CdSe nanoparticles” Thin Solid Films, 2005,489, 296.【SCI, Rank 68/214, IF:1.767】

 

1.      國家衛生研究院電子報 第 281 期 2008-12-12. 多功能性中孔洞奈米矽球用於體內追蹤與光動力治療之研究現況。Functionalization of Mesoporous Silica Nanoparticles for In Vivo Optical Imaging and Photodynamic Therapy: Current Status.

2.      國家衛生研究院電子報 第 364 期 2010-07-29.利用奈米金棒表面覆蓋二氧化矽之複合材料增益光聲影像。NHRI Investigators develop enhanced photoacoustic stability of gold nanorods by silica matrix confinement.

3.      國家衛生研究院電子報 第 380 期 2010-11-18. 三功能性中孔洞奈米矽球運用於癌症診斷治療之研究現況--影像追蹤、定位、與光動力治療三項的組合。NHRI researchers develop tri-functionalized mesoporous silica nanoparticles for use as comprehensive cancer theranostics.

4.      Highlight in Chemical biology from across RSC Publishing. “Three-in-one nanoparticles treat cancer.” 23 June 2010.

 

1.      Cheng, S.H., Hsieh, C.C., Yang, C.S., Tseng, F.G., Chou, P.T., and Lo, L.W. Intra-mesoporous silica nanoparticle energy transfer for two-photon photodynamic therapy. 2010 World Molecular Imaging Congress, Kyoto, Japan, September 8-11, 2010.

2.      Cheng, S.H., Li, F.C., Yang, C.S., Tseng, F.G., Dong, C.Y., and Lo, L.W. Dynamic monitoring of surface charge-mediated sub-hepatic biodistribuion of mesoporous silica nanoparticles using intravital multiphoton microscopy. 2010 World Molecular Imaging Congress, Kyoto, Japan, September 8-11, 2010.

3.      Souris, J.S., Lee, C.H., Cheng, S.H., Chen, C.T., Yang, C.S., Ho, J-a.A., Mou, C.Y., and Lo, L.W. Charge-mediated hepatobiliary transport and excretion of fluorescent mesoporous silica nanoparticles. 2010 World Molecular Imaging Congress, Kyoto, Japan, September 8-11, 2010.

4.      Souris, J.S., Cheng, S.H., Chen, M.C., Lee, C.H., Tseng, F.G., Yang, C.S., Mou, C.Y., Chen, C.T., and Lo, L.W. Tri-functionalization of mesoporous silica nanoparticles for diagnosis and therapy. 2010 World Molecular Imaging Congress, Kyoto, Japan, September 8-11, 2010.

5.      Huang, I.P., Cheng, S.H., Lee, C.H., Yang, C.S., Mou, C.Y., and Lo, L.W. Functionalization of mesoporous silica nanoparticles for the pH-sensitive controlled release of anti-cancer drugs. NanoSmat-2009, Rome, Italy, October 19-22, 2009.

6.      Cheng, S.H., Chen, M.C., Lee, C.H., Yang, C.S., Tseng, F.G., Mou, C.Y., and Lo, L.W. In vitro study of cyclic-RGD modified near-infrared mesoporous silica nanoparticles for cancer targeting and therapeutics. NanoSmat-2009, Rome, Italy, October 19-22, 2009.

7.      Cheng, S.H., Chen, M.C., Lee, C.H., Yang, C.S., Tseng, F.G., Mou, C.Y., and Lo, L.W. In vitro study of functionalized near-infrared mesoporous silica nanoparticles for cancer targeting delivery. 1^st Nano Today Conference, Singapore, August 2-5, 2009.

8.      Cheng, S.H., Vinogradov, S.A., Lee, C.H., Yang, C.S., Tseng, F.G., Mou, C.Y., and Lo, L.W. Theranostic mesoporous silica nanoparticles for photodynamic therapy. 2008 World Molecular Imaging Congress, the Acropolis Convention Center, Nice, France, September 10-13, 2008.

 

 

1.          2009 Nano Today Student Traval Award, 1st Nano Today Conference.